Functional binder generation

Therabodies™ are functional antibody fragments based on a single immunoglobulin domain.

Discovery process

To generate Therabodies™, camels or llamas are immunized with purified antigens and the antibody variable fragment gene is then amplified from the lymphocytes of the immunized animal.

Once the antibody fragments are selected against immobilised antigens, each fragment is expressed and characterized in various functional assays.

The discovered functional antibody fragments display strong affinity (nM), which can be used in animal models to validate the implication of the targeted antigen in a certain disease as well as the therapeutic potential of the Therabody™.