Purification of membrane proteins in a functional state remains risky and challenging. As a result, ready-to-use purified receptors are not generally available as fully characterised products. Theranyx is today in a position to propose batches of active receptors according to our catalogue, which should strongly enhance the possibilities of studying this important class of drug targets.
Our products intend to aid researchers in a more diverse and precise characterization of receptor interaction with chemical compounds, natural extracts, peptides and proteins.
Theranyx also proposes custom fee-for-service membrane receptor purification of any target of interest for your research activity. To reach expression yield compatible with receptor purification, our company is conducting parallel expression in four different cell lines (HEK, CHO, Sf9 and S2) using two alternative constructs. Our researchers pay a particular attention to the functionality of the expressed receptor. Purification is conducted after screening solubilisation conditions to reach optimal receptor integrity and monodispersity.
It is our intention over the upcoming years to be able to propose an exhaustive collection of purified receptors as ready-to-use product, with potential application in the following: