Our team has developed a robust platform for the preparation of purified, stabilized and functional membrane proteins facilitating the development of novel therapeutic molecules. Our platform enables us to engineer and purify membrane receptors in stable and functional conformations that retain their drug-binding characteristics.
Our approach will promote contemporary drug discovery through the application of biophysical analysis of ligand-receptor interactions, crystallization and structure-based design for ion channels and other membrane receptors. In addition to its receptor expression/purification platform, Theranyx develops wide-ranging and compact binder libraries with various properties capable of competing with human antibodies for strategic binding sites involved in the modulation of membrane protein function. This unique approach is expected to radically improve the chances of developing safe and highly selective therapeutics.